Endocrine Abstracts

Introduction: The 1-mg overnight low-dose dexamethasone suppression test is used as a screening tool when Cushing’s syndrome is suspected. However, the biological confirmation of this syndrome is based upon the measurement of 24-hour urinary free cortisol and low-dose dexamethasone suppression test (Liddle test). The aim of this study was to assess the performance of the 1-mg overnight low-dose dexamethasone suppression test in the diagnosis of Cushing’s syndrome.</p...

Introduction: The sellar region is known as a low-risk brain metastasis area. The prevalence of pituitary metastasis represents 1% of all surgical tumors of the pituitary gland. In most cases, pituitary metastasis is identified in patients with a prior history of cancer. In a few cases, it can reveal the primary tumor. The aim of this study was to assess clinical and paraclinical features of pituitary metastasis. Methods: This was a retrospective and des...

Introduction: Non-functional pituitary adenomas (NFPAs) represent 30% of all pituitary adenomas and not associated with clinical evidence of hormonal hypersecretion. The aim of our study was to describe the clinical and paraclinical aspects of NFPAs.Methods: This is a retrospective descriptive study concerning 40 patients who were hospitalized in the endocrinology department of Rabta hospital in Tunis between January 2014 and December 2020. Clinical and ...

Introduction: Swyer syndrome is a rare sex development disorder characterized by pure 46 XY gonadal dysgenesis. It is associated with aberrations in testicular determination and differentiation leading to a female morphotype with presence of external and internal female genitalia, undifferentiated fibrous gonads, a male karyotype and hypergonadotropic hypogonadism. We present the case of a 46 XY adolescent female with complete gonadal dysgenesis diagnosed following her hospita...

Introduction: Papillary thyroid carcinoma is one of the most prevalent endocrine tumors. Adrenocorticotropic hormone (ACTH) dependent Cushing’s syndrome is a rare disease. We report a rare case of coexistence of papillary thyroid carcinoma and ACTH-dependent Cushing’s syndrome.Observation: A 59-year-old man, was admitted to our endocrinology department for exploration of bilateral adrenal incidentalomas discovered in an abdominal CT scan done i...

Introduction: Besides insulin allergy, several other forms of insulin intolerance are possible. Adipose panniculitis (AP) is an acute form.Purpose: Describe the clinical, paraclinical and evolution of AP.Clinical case: 64-year-old patient, type 2 diabetic for 24 years on premixed human insulin for 10 years. He consults for itchy erythematous lesions at the insulin injection sites. The lesion begins with an immediate pruritus then a...

Introduction: Hyperuricemia is a common metabolic feature in patients with metabolic syndrome.Aim: The aim of our work is to study the correlation between uric acid level and the metabolic profile in hypertensive type 2 diabetic patients.Methods: This is a retrospective descriptive study of hypertensive type 2 diabetic patients followed in the endocrinology department of Hedi Chaker University Hospital of Sfax, Tunisia between 2019...

Introduction: Autoimmune hepatitis (AIH) is a generally progressive and chronic liver disease that can occur both in children and adults. Although the cause of AIH is unknown, aberrant auto-reactivity is thought to have a role in its pathogenesis. The diagnosis is based on clinical presentation, biological and histological findings. Like other autoimmune diseases (AD), AIH can be associated with one or more AD either organ-specific or non-organ specific AD. <p class="abste...

Introduction: Graves’ disease (GD) is the most common cause of hyperthyroidism in pediatric patients, up to 95% in some studies.Observation: We report the observation of a 6-year-old female who consulted for a behavioral disorder made of agitation and lack of concentration. She had a family history of autoimmune thyroid disease. On examination, an accelerated statural growth rate of +2DS was noted. She had a significant palpebral retraction without ...

Introduction: Cardiothyreosis is the consequence of the effects of excess free thyroid hormones on the vascular wall and myocardium. This complication is the most serious aspect of hyperthyroidism. Rhythm disorders and heart failure are the most frequently noted. The prevalence of coronary insufficiency is lower. The aim of this study is to evaluate the characteristics of coronary insufficiency in patients with hyperthyroidism.Method: This is a retrospec...